The Immunopathology of Lung Disease

Severe Murine Lung Immunopathology

Immunopathology of Chagas disease.

The main clinical forms of Chagas disease (acute, indeterminate and chronic cardiac) present strong evidences for the participation of the immune system on pathogenesis. Although parasite multiplication is evident during acute infection, the intense acute myocarditis of this phase exhibits clear ultrastructural signs of cell-mediated immune damage, inflicted to parasitized and non-parasitized m...

Immunopathology of Beh9et's disease

Behqet's disease (BD) is best considered as a systemic vasculitis in which recurrent orogenital ulceration is a prominent feature. In 1937 Hulusi Behqet described the syndrome that bears his name' but the term 'BehNet's disease' is now used in preference to 'Behqet's syndrome'. Behqet, himself, recognized the problems related to its diagnosis for which there remains no diagnostic test. BD is ra...

Evolution on the immunopathology of Chagas disease.

Immunopathology of cardiomyopathy in the experimental Chagas disease.

The mechanisms by which Trypanosoma cruzi causes cardiomyopathy and induces neuronal destruction are discussed in this paper. The results suggest that autoimmunity in the chronic phase is the main cause of the progressive cardiac destruction, and that autoreactivity is restricted to the CD4+ T cell compartment. During the acute phase, the neuronal and cardiac fiber destruction occurs when ruptu...